Flash forward a year and a half, and Kate’s disease has advanced rapidly, necessitating around-the-clock care. All goes well until Kate, a former concert pianist, takes to the keys and finds her right hand shaking uncontrollably. An ominous prologue introduces upper-crust Houston couple Kate (Swank) and Evan (Josh Duhamel) as they host a cocktail party in their impressive, antiseptic modernist home. While the film’s last two acts begin to deepen its characters in generally satisfying ways, “You’re Not You” throws down its initial gauntlet with an off-putting lack of subtlety.

There are still some genuinely affecting individual scenes and keen observations to be found, however, and Swank’s performance alongside Emmy Rossum should help draw moderate yet appreciative attention to the film on VOD. Wolfe’s “You’re Not You.” Unfortunately, the film calls on her to play a disease more often than a character, and this well-intentioned weepie never quite rises far enough above its movie-of-the week architecture to hit all its intended emotional pressure points.

Playing a fortysomething patrician woman afflicted with ALS, Hilary Swank gives a sensitive, nuanced illustration of the disease’s horrible physical toll in George C.